Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Good
Based on 205 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
0
We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Read More
8
We explored how nattokinase (NK), a strong clot-buster, can be delivered effectively using NK-conjugated magnetite nanoparticles (NK-MNPs). These nanoparticles were designed to release NK directly at the site of a thrombus and showed promising results in sustained release and thrombolytic potential.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
Read More
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Read More
Most Useful Reviews
9
Relieved arrhythmia symptoms
235 people found this helpful
Nattokinase is a unique enzyme essential for preventing various diseases, significantly aiding heart function. It improves blood circulation, dissolves blood clots, reduces the risk of cardiovascular disease, and promotes healthy cholesterol levels. After experiencing severe symptoms, I took nattokinase and felt improvements with each pill, eventually reducing my dosage as I felt better.
Read More
9
Effective thrombolytic therapy
190 people found this helpful
Nattokinase is a remarkable enzyme used for cardiovascular problems, especially in Asia, and is gaining recognition in the West for its anticoagulant properties. It shows promise in treating cardiovascular diseases and is a reliable choice for effective and economical treatment.
Read More
9
Natural blood thinner
122 people found this helpful
Works exceptionally well, replacing Xarelto. Nattokinase enhances blood fluidity, helping maintain health. It is excellent for lowering cholesterol, improving immunity, and relieving varicose veins, thus beneficial for cardiovascular disease. I've been taking it for myself and my loved ones, and the results are impressive.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
- All Researches
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Read More
8
We examined how a new treatment combining nattokinase with manganese oxide nanozymes might help with acute myocardial infarction, a serious heart condition often caused by blood clots.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Read More
8
We explored the effectiveness of a specific strain of Bacillus subtilis in producing nattokinase to enhance fermented milk's health benefits. This probiotic contributed to significant thrombolytic activity, which helps prevent blood clots, a major factor in cardiovascular disease.
Our study demonstrated that fermented milk from B. subtilis could inhibit thrombosis in mice, indicating a promising way to integrate healthy options in our diets. Notably, sensory evaluations revealed that this functional fermented milk was well-accepted, similar to traditional options.
Overall, our findings highlight the potential of B. subtilis JNFE0126-fermented milk as a delicious, healthful alternative that may help reduce cardiovascular risks.
Our study demonstrated that fermented milk from B. subtilis could inhibit thrombosis in mice, indicating a promising way to integrate healthy options in our diets. Notably, sensory evaluations revealed that this functional fermented milk was well-accepted, similar to traditional options.
Overall, our findings highlight the potential of B. subtilis JNFE0126-fermented milk as a delicious, healthful alternative that may help reduce cardiovascular risks.
Read More
8
We explored how nattokinase (NK), a strong clot-buster, can be delivered effectively using NK-conjugated magnetite nanoparticles (NK-MNPs). These nanoparticles were designed to release NK directly at the site of a thrombus and showed promising results in sustained release and thrombolytic potential.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
Read More
8
Nattokinase-enhanced nanocomposites for thrombolysis
We explored the potential of nattokinase, a promising thrombolytic agent, by creating stable nanocomposites using polylysine dendrimers. Through innovative methods, we ensured that nattokinase was effectively protected from environmental factors, enhancing its stability and activity.
When combined at a 1:30 molar ratio, these nanocomposites demonstrated a remarkable thrombolysis rate, effectively targeting blood clots while minimizing risk of complications. This research indicates that these nanostructures could pave the way for safer and more effective thrombolytic therapies.
When combined at a 1:30 molar ratio, these nanocomposites demonstrated a remarkable thrombolysis rate, effectively targeting blood clots while minimizing risk of complications. This research indicates that these nanostructures could pave the way for safer and more effective thrombolytic therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 205 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved arrhythmia symptoms
235 people found this helpful
Nattokinase is a unique enzyme essential for preventing various diseases, significantly aiding heart function. It improves blood circulation, dissolves blood clots, reduces the risk of cardiovascular disease, and promotes healthy cholesterol levels. After experiencing severe symptoms, I took nattokinase and felt improvements with each pill, eventually reducing my dosage as I felt better.
Read More
9
Effective thrombolytic therapy
190 people found this helpful
Nattokinase is a remarkable enzyme used for cardiovascular problems, especially in Asia, and is gaining recognition in the West for its anticoagulant properties. It shows promise in treating cardiovascular diseases and is a reliable choice for effective and economical treatment.
Read More
9
Natural blood thinner
122 people found this helpful
Works exceptionally well, replacing Xarelto. Nattokinase enhances blood fluidity, helping maintain health. It is excellent for lowering cholesterol, improving immunity, and relieving varicose veins, thus beneficial for cardiovascular disease. I've been taking it for myself and my loved ones, and the results are impressive.
Read More
9
Improves blood circulation
118 people found this helpful
Nattokinase, derived from natto, significantly enhances blood flow and circulation. It offers a strong alternative to aspirin for maintaining blood density. This enzyme promotes various health benefits, including lowering cholesterol levels and boosting immunity. I've seen improvements in pressure regulation and reduced swelling in my lower legs. I appreciate nattokinase's extensive preventive capabilities against cardiovascular diseases as well as its positive effects on my overall health.
Read More
9
Heart disease prevention
78 people found this helpful
Nattokinase effectively dissolves blood clots and improves circulation while lowering LDL cholesterol and blood pressure. This enzyme is crucial given the prevalence of cardiovascular diseases. I took one capsule daily with my husband, and we both experienced lower blood pressure levels. I highly recommend this supplement as it's an easy and cost-effective preventive measure against heart issues.
Read More
Frequently Asked Questions
9
Miracle herb experience
19 people found this helpful
Three years ago, I started taking Nattokinase for my cardiovascular disease and it transformed my daily life. After just one day, I was able to work longer without chest pain and stopped taking Aspirin. It's a miracle herb without the stomach irritation that Aspirin causes.
9
Heart disease prevention
78 people found this helpful
Nattokinase effectively dissolves blood clots and improves circulation while lowering LDL cholesterol and blood pressure. This enzyme is crucial given the prevalence of cardiovascular diseases. I took one capsule daily with my husband, and we both experienced lower blood pressure levels. I highly recommend this supplement as it's an easy and cost-effective preventive measure against heart issues.
9
Improves circulation
33 people found this helpful
As someone with a history of heart disease, Nattokinase has been essential for me. Following a scare, I started combining this supplement with a healthy diet and exercise, leading to significant improvements in my symptoms. It even aids absorption in the gastrointestinal tract, which has enhanced my overall health.
9
Improves blood circulation
118 people found this helpful
Nattokinase, derived from natto, significantly enhances blood flow and circulation. It offers a strong alternative to aspirin for maintaining blood density. This enzyme promotes various health benefits, including lowering cholesterol levels and boosting immunity. I've seen improvements in pressure regulation and reduced swelling in my lower legs. I appreciate nattokinase's extensive preventive capabilities against cardiovascular diseases as well as its positive effects on my overall health.
7
Safe alternative to aspirin
32 people found this helpful
I replaced aspirin with Nattokinase for better cardiac health. I usually take one capsule at night, but I’ll adjust the dosage. I carry it during flights to prevent thrombosis. It is beneficial for cardiovascular disease, hypertension and other related conditions.
8
Fights atherosclerosis
20 people found this helpful
Nattokinase is a potent proteolytic enzyme I take on an empty stomach. It effectively thins the blood and combats atherosclerotic plaques, which is essential for cardiovascular disease prevention. The combination of nattokinase and serrapeptase also aids in overall inflammation relief.
9
Improves oxygen delivery
69 people found this helpful
Having suffered from thrombosis, I turned to nattokinase based on positive reviews. This enzyme significantly enhances oxygen delivery to tissues and lowers cholesterol, vital for cardiovascular disease prevention. I take one capsule daily to improve blood fluidity and have noticed benefits like reduced muscle pain and better overall wellbeing.
9.5
We explored an innovative approach to treating blood clots using specially designed magnetic nanorobots that deliver nattokinase directly to targeted areas. These tiny robots are not only able to navigate through blood vessels but also use a combination of magnetic fields to break down clots effectively.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
8
We investigated the effectiveness of nattokinase in managing carotid artery atherosclerosis and blood lipids over a 26-week treatment with 82 patients in two groups: one receiving nattokinase and the other statins. Both groups showed reductions in carotid plaque size and artery thickness, with the nattokinase group experiencing notably larger reductions.
While both treatments improved lipid profiles, the statin group saw more significant cholesterol reductions. Notably, nattokinase increased HDL levels, showing promise as a potential alternative to statins in managing atherosclerosis, though its effects appear unrelated to lipid changes.
While both treatments improved lipid profiles, the statin group saw more significant cholesterol reductions. Notably, nattokinase increased HDL levels, showing promise as a potential alternative to statins in managing atherosclerosis, though its effects appear unrelated to lipid changes.
0
We examined how nattokinase affects the progression of atherosclerosis and related biomarkers in a double-blind trial involving 265 participants averaging 65 years old, who had no cardiovascular disease. Participants received either nattokinase or a placebo for three years.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
7
Nattokinase shows promise in thrombosis
We explored the potential of nattokinase (NK) in tackling cardiovascular disease, particularly its ability to address thrombosis—an ongoing challenge due to the risks of bleeding from traditional treatments.
Our research demonstrated that NK not only alleviated inflammation and oxidative stress in mouse models but also improved kidney health affected by inflammation.
NK showed remarkable effects by inhibiting key inflammatory responses and reducing harmful proteins related to clot formation. While its promise is evident in early research, further studies are necessary to fully understand its benefits for human cardiovascular health.
Our research demonstrated that NK not only alleviated inflammation and oxidative stress in mouse models but also improved kidney health affected by inflammation.
NK showed remarkable effects by inhibiting key inflammatory responses and reducing harmful proteins related to clot formation. While its promise is evident in early research, further studies are necessary to fully understand its benefits for human cardiovascular health.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Gao R, Zhang W, Chen X, Shen J, Qin Y, et al. Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis. ACS Nano. 2024;18:29492. doi:10.1021/acsnano.4c04331
- Zhang X, Tong Y, Wang J, Lyu X, Yang R. Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity. J Dairy Sci. 2021;104:9437. doi:10.3168/jds.2020-19756
- Gallelli G, Di Mizio G, Palleria C, Siniscalchi A, Rubino P, et al. Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases. Nutrients. 2021;13. doi:10.3390/nu13062031
- Liu S, Zhu J, Liu C, Li J, Li Z, et al. Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis. Pharmazie. 2021;76:145. doi:10.1691/ph.2021.0155
- Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147
- Wu H, Wang Y, Zhang Y, Xu F, Chen J, et al. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020;32:101500. doi:10.1016/j.redox.2020.101500
- Pan X, Liang P, Teng L, Ren Y, Peng J, et al. Study on molecular mechanisms of nattokinase in pharmacological action based on label-free liquid chromatography-tandem mass spectrometry. Food Sci Nutr. 2019;7:3185. doi:10.1002/fsn3.1157
- Wu C, Gao C, Lü S, Xu X, Wen N, et al. Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis. J Biomed Mater Res A. 2018;106:440. doi:10.1002/jbm.a.36232
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. doi:10.3760/cma.j.issn.0376-2491.2017.26.005
